Description
N-acetyl-β-glucosaminidase (NAG) is a lysosomal enzyme that is present in renal proximal tubular cells and increasingly excreted as an indicator of renal tubular dysfunction. NAG is released from proximal tubule epithelial cells injured by AKI and strongly correlates with the extent of proximal tubule damage [160]. In addition, a previous study demonstrated that the activities of NAG, alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) in the urine of children with upper obstructive uropathy were 2- to 10-fold higher than those in healthy children [161].
Regarding CKD, few studies have investigated the relationship between urinary NAG and ESKD; however, urinary NAG was not associated with CKD progression or eGFR declines after adjustments for traditional risk factors of CKD progression [162–164]. A high salt intake in normotensive rats was not associated with a significant increase in NAG